The physiological and pathological roles and applications of sialyl Lewis x, a common carbohydrate ligand of the three selectins

F Jin, F Wang - Glycoconjugate Journal, 2020 - Springer
… derivative of the Lewis blood group antigen structure, also is a … link between ligand binding
and E-selectin conformational … sLe x presenting on the mucin protein) for detecting breast …

[PDF][PDF] Studies of the role of sialyl Lewis X antigen and E selectin ligands in colorectal cancer

FM Deschepper - 2020 - run.unl.pt
… rise to the core 1 to 4 of mucin type O-glycan or to the Tn antigen which can be sialylated.
The core 1 disaccharide structure is called T antigen and, as Tn antigen, can be sialylated. …

[HTML][HTML] C-type lectins

RD Cummings, E Chiffoleau, Y van Kooyk… - … [Internet]. 4th edition, 2022 - ncbi.nlm.nih.gov
… as the sialyl-Lewis x antigen (SLe x ) and its isomer sialyl-Lewis a (… E-selectin is also reported
to bind sialofucosylated … PSGL-1 contains 16 decapeptide repeating units (mucin repeats) …

Glycosylation changes in cancer

SL Bellis, CA Reis, A Varki, R Kannagi, P Stanley - 2022 - europepmc.org
… by addition of SLe x and sialyl-Lewis a (SLe a ) structures on either … cells, and mucin-like
tumor antigens carrying SLe x and SLe … of E-selectin in mouse liver causes carcinoma cells that …

The biology of E-selectin ligands in leukemogenesis

E Ales, R Sackstein - Advances in Cancer Research, 2023 - Elsevier
… their prototypical binding determinant, sialyl Lewis X (sLeX; … The PSGL-1 molecule (CD162)
is a homodimeric, mucin-like … as “anti-cutaneous lymphocyte antigen”). This is tautological …

Nucleolin-Sle A glycoforms as E-selectin ligands and potentially targetable biomarkers at the cell surface of gastric cancer cells

E Fernandes, R Freitas, D Ferreira, J Soares… - Cancers, 2020 - mdpi.com
… of sialyl Lewis X (SLeX) levels [16]. It is also well documented that these sialylated Lewis
antigens mediate binding to E-selectin, … support that NCL carrying sialylated antigens may help …

Peracetyl N-cyclobutanoyl-D-mannosamine enhances expression of sialyl-Lewis X (sLeX / CD15s) and adhesion of leukocytes

A Tasneem, S Parashar, S Aittan, T Jain, C Chauhan… - bioRxiv, 2021 - biorxiv.org
… to be processed through both the mucin-type O-glycosylation (… the binding of sLeX to its
endogenous receptor E-selectin (… Cutaneous lymphocyte antigens (CLA) carry sLeX glycans, …

Glycosylation and metastases

D Josic, T Martinovic, K Pavelic - Electrophoresis, 2019 - Wiley Online Library
… as heparin sulfate and altered mucin glycosylation. O-Linked β-… , more intense antigen
formation (Lewis X and sialyl-Lewis X). It … E-selectin is considered an initial adhesion event during …

[HTML][HTML] Esophageal, gastric and colorectal cancers: Looking beyond classical serological biomarkers towards glycoproteomics-assisted precision oncology

E Fernandes, J Sores, S Cotton, A Peixoto… - Theranostics, 2020 - ncbi.nlm.nih.gov
Sialyl Lewis antigens biosynthesis is a complex process … cells and gain of E-selectin
binding capacity of cancer cells, … (TAG-72) mucin carrying the STn antigen 75 , whereas CA19-…

[PDF][PDF] Glycan engineering using synthetic ManNAc analogues enhances sialyl-Lewis-X expression and adhesion of leukocytes

A Tasneem, S Parashar, T Jain, S Aittan, J Rautela… - scholar.archive.org
… to be processed through both the mucin-type Oglycosylation (… binding studies have
established that E-selectin binding to … Cutaneous lymphocyte antigens (CLA) carry sLeX glycans …